TABLE 3

Efficacy parameters for both compounds with log fit against P. falciparum Pf3D70087/N9

Parameter by method of estimation (dosing regimen)Goodness of fitMean
Sulfoxide (quadruple dose)
    ED90 (mg kg–1)0.96820.12
    AUCED90 (µg h ml–1)0.96810.39
    CmaxED90 (µg ml–1)0.96810.02
Sulfone (quadruple dose)
    ED90 (mg kg–1)0.96270.12
    AUCED90 (µg h ml–1 day–1)0.96210.20
    CmaxED90 (µg ml–1)0.96200.03
Sulfoxide (single dose)
    ED90 (mg kg–1)0.95380.51
    AUCED90 (µg h ml–1)0.95441.33
    CmaxED90 (µg ml–1)0.95380.09
Chloroquine
    ED90 (mg kg–1)0.99942.80
    AUCED90 (µg h ml–1)0.94651.79