TABLE 1

Antibacterial activity of C109 against select Gram-negative and Gram-positive bacteria

StrainFeaturesMIC (µg/ml)aSource
Acinetobacter baumannii ATCC 19606Reference strain16ATCC
Burkholderia cenocepacia K56-2ET12 lineage cystic fibrosis clinical isolate873
Burkholderia cenocepacia J2315ET12 lineage cystic fibrosis clinical isolate874
Enterobacter aerogenes ENT001Urine meropenem-resistant isolate32A. Kumar
E. aerogenes ATCC 13048Reference strain8A. Kumar
Escherichia coli ATCC 25922Reference strain8ATCC
E. coli 117782ESBL-positive clinical isolate4G. Zhanel
E. coli 120955ESBL-positive clinical isolate8G. Zhanel
Klebsiella pneumoniae 119178ESBL-positive clinical isolate32G. Zhanel
Mycobacterium abscessus 13NC740779Ciprofloxacin-resistant clinical isolate4H. Adam
M. abscessus 14NF251095Ciprofloxacin-resistant clinical isolate4H. Adam
M. abscessus 14NJ168168Ciprofloxacin-resistant clinical isolate4H. Adam
M. abscessus 16NH386647Ciprofloxacin-resistant clinical isolate8H. Adam
Pseudomonas aeruginosa PAO1Common lab strain, from burn wound256A. Kumar
P. aeruginosa PA7Nonrespiratory clinical isolate128 A. Kumar (75)
P. aeruginosa PA14High virulence burn wound isolate>128Joseph Lam (76)
Salmonella enterica serovar TyphimuriumSGI1 genomic island; multidrug resistant6477
Serratia marcescens Db11Streptomycin-resistant strain1678
Staphylococcus aureus ATCC 25923Methicillin-sensitive reference strain4ATCC
  • a MIC values are given as the median of three biological replicates.