TABLE 3

C109 has additive effects with common antibiotics used against B. cenocepacia

AntibioticK56-2 MIC
alone (μg/ml)
K56-2 FIC
index with C109a
InterpretationJ2315 MIC
alone (μg/ml)
J2315 FIC
index with C109a
Interpretation
Meropenem320.625Additive320.508Additive
Piperacillin80.625Additive2560.560Additive
Tobramycin5120.625Additive5122Additive
Ciprofloxacin21Additive82Additive
Ceftazidime640.625AdditiveNDND
Doxycycline40.625AdditiveNDND
Novobiocin80.75AdditiveNDND
Trimethoprim80.75Additive5122Additive
Chloramphenicol321AdditiveNDND
  • a Reported is the median FIC index from three biological replicates. ND, not determined.