TABLE 8

Spontaneous mutational frequencies of C. acnes with sarecycline, vancomycin, and minocycline

C. acnes strainAgentConcn (µg/ml)MIC multipleSpontaneous mutation frequency
1286Sarecycline88<7.5 × 10−11
44<7.5 × 10−11
Vancomycin48<7.5 × 10−11
24<7.5 × 10−11
Minocycline28<7.5 × 10−11
14<7.5 × 10−11
1713Sarecycline48<1.35 × 10−10
24<1.35 × 10−10
Vancomycin48<1.35 × 10−10
24<1.35 × 10−10
Minocycline28<1.35 × 10−10
14<1.35 × 10−10
5004Sarecycline487.87 × 10−10
247.87 × 10−10
Vancomycin48<7.87 × 10−10
24<7.87 × 10−10
Minocycline28<7.87 × 10−10
14<7.87 × 10−10
5030Sarecycline489.35 × 10−10
241.4 × 10−9
Vancomycin48<9.35 × 10−10
24<9.35 × 10−10
Minocycline28<9.35 × 10−10
14<9.35 × 10−10