TABLE 8

Effect of human serum on NVR 3-778 antiviral activities

Human serum (%)EC50 (µM)EC50 fold shiftaEC90 (µM)EC90 fold shifta
00.40 ± 0.1011.5 ± 0.411.0
101.8 ± 0.514.56.9 ± 0.94.5
23.7 ± 1.09.315.9 ± 6.310.3
406.3 ± 2.015.823.5 ± 11.615.2
  • a Ratio of the mean EC50 and EC90 values in the presence of human serum compared to those without human serum. The EC50 and EC90 values shown are the mean value ± standard deviation from at least three independent studies.