TABLE 2

LDM LBP residues within 4 Å of VT-1161a

SRS no. or groupScLDM6×His + VT-1161N-truncCaLDM6×His + VT-1161
SRS1A124AYAHLTTPVFGKGVIYDCP143E116AYKHLTTPVFGKGVIYDCP135
SRS4I304ANLLIGVLMGGQHTSAA321I297ANLLIGILMGGQHTSAS314
SRS5H378PLHSLFR385M374PLHSIFR381
SRS6D505FTSMVTLPTG515D504YSSMVVLPTE514
Helix A′A69V70, Y72GM74A61A62, Y64GQ66
Helix FF′F236, P238, F241F228, P230, F233
Additional residues in
LBP surface
V66, P76 L95L96, R98, M100, L147, Q150K151,
V154, I239, V242, H405, I471
F58, P68 L87L88 K90, M92 L139, Q142K143,
A146, I231, V234, Y401, I471
  • a Amino acid residues in the LBP are shown in italics, and residues within 4 Å of VT-1161 are in bold.