TABLE 4

Activity of sarecycline and comparators against aerobic Gram-negative bacilli

OrganismNo. of isolatesAgentMIC (µg/ml)
Range50%90%
E. cloacae30Sarecycline0.25 to >6432>64
Tetracycline0.5 to >642>64
Doxycycline0.06 to >32232
Minocycline≤0.03 to >32116
E. coli33Sarecycline2 to >6416>64
Tetracycline1 to >642>64
Doxycycline0.5 to >32232
Minocycline0.25 to >3218
K. pneumoniae31Sarecycline16 to >64>64>64
Tetracycline1 to >648>64
Doxycycline1 to >328>32
Minocycline1 to >324>32
P. mirabilis30Sarecycline>64>64>64
Tetracycline16 to >643264
Doxycycline32 to >32>32>32
Minocycline8 to >3216>32
Salmonella spp.35Sarecycline8 to >6416>64
Tetracycline1 to >642>64
Doxycycline2 to >32232
Minocycline1 to >3228