TABLE 10

Activity of sarecycline and comparators against tetracycline-resistant S. aureus clinical isolates

S. aureus strain genotypeNo. of isolatesMIC (μg/ml)
SarecyclineTetracyclineDoxycyclineMinocycline
Wild type200.06–0.250.06–0.250.06–0.250.125–0.5
tet(K)40.125–116–641–40.25–1
tet(M)2864164
tet(38)242–41–20.5
tet(M), tet(38)216–326488–16