TABLE 2

Limitations of current therapeutic options

IssueColistinTigecyclineMinocyclineAmikacinSulbactam
Pharmacokinetic issues
    Narrow therapeutic spectrum
    Low or inconsistent drug levels
        Plasma
        Lung
        Urine
    Toxicity
        Nephrotoxicity
        Neurotoxicity
Resistance
    High resistance rates
    Heteroresistance
    Breakthrough
Only in combination
Increased mortality