TABLE 2

Activity of sarecycline and comparators against high-level erythromycin-resistanta C. acnes clinical isolates

C. acnes strainMIC (μg/ml)
SarecyclineTetracyclineDoxycyclineMinocycline
157584842
160951110.25
160991632168
165610.5110.25
206604421
206614421
213684421
213870.50.50.250.12
213880.510.50.25
  • a High-level erythromycin resistance was an erythromycin MIC of ≥128 µg/ml.