TABLE 6

Antiviral activities of NVR 3-778 and LMV in PHH during de novo infectiona

MoleculeNVR 3-778LMV
EC50 (µM)EC90 (µM)EC50 (µM)EC90 (µM)
HBV DNA0.81 ± 0.185.4 ± 2.00.016 ± 0.0100.066 ± 0.010
HBsAg4.8 ± 0.9810.2 ± 3.0>30>30
HBeAg4.5 ± 0.828.9 ± 1.2>30>30
Intracellular HBV RNA3.7 ± 0.2211.6 ± 2.7>30>30
β-Actin mRNA10 μM < CC50 <30 μMb10 μM < CC90 <30 μMb>30>30
  • a Mean EC50 values and standard deviations were determined using PHH from three different donors. CC50, 50% cytotoxic concentration.

  • b Inhibition of β-actin mRNA by NVR 3-778 was observed only at the highest concentration tested (30 μM).