TABLE 5

Antiviral activities of NVR 3-778 and LMV against wild-type HBV and HBV core protein variants

HBV variantNVR 3-778 EC50 (µM)aEC50 FCbLMV EC50 (µM)aLMV EC50 FCb
NVR 3-778NVR-010-001-E2cBay 41-4109c
Wild type0.23 ± 0.111110.26 ± 0.181
Y118F1.7 ± 0.77.43.78.20.33 ± 0.221.3
T109S0.77 ± 0.273.30.430.400.22 ± 0.0800.96
T109M0.28 ± 0.131.22.83.70.22 ± 0.100.96
T109I0.15 ± 0.0610.659.2210.31 ± 0.171.2
I105L0.34 ± 0.131.50.490.440.35 ± 0.191.3
I105T1.5 ± 0.36.51.21.50.26 ± 0.0561.0
I105V0.41 ± 0.111.81.31.30.22 ± 0.0630.84
  • a Mean EC50 values and standard deviations from at least three independent studies determined in HepG2 cells.

  • b FC, fold change. The EC50 fold change refers to the ratio of the mean EC50 value for the core variants over that for wild-type HBV.

  • c Previously published results (5) for comparison with NVR 3-778.