TABLE 2

Antiviral activities of NVR 3-778 in HepG2 cells transiently transfected with plasmids containing representative HBV isolates from GT A to Ha

HBV GTEC50 (µM)No. of expt
MeanSDRange
A0.380.150.18–0.587
B0.200.0640.12–0.3110
C0.340.130.21–0.547
D0.430.0860.36–0.577
E0.580.0440.52–0.646
F0.560.100.39–0.646
G0.250.130.13–0.487
H0.580.150.34–0.756
  • a Intracellular encapsidated rcDNA levels were monitored and compared with those in untreated cells. Mean EC50 values and standard deviations were determined from multiple independent experiments, as indicated.