TABLE 6

Efficacy of sarecycline and comparators against S. aureus and E. coli in a murine systemic model of infection at 48 h postinfection

Antibacterial agentS. aureus RN450-1E. coli PBS1478
MIC (μg/ml)PD50 (mg/kg)MIC (μg/ml)PD50 (mg/kg)
Sarecycline0.060.25440
Doxycycline0.060.30.55.72
Minocycline0.060.0316.95