TABLE 9

Spontaneous mutational frequencies of S. aureus and S. epidermidis isolates with sarecycline and vancomycin

Test organismAgentConcn (µg/ml)MIC multipleMean inoculum size (no. of CFU)Spontaneous mutation frequency
S. aureus 0100Sarecycline481.74 × 108<5.75 × 10−9
241.74 × 1088.62 × 10−9
Vancomycin881.74 × 108<5.75 × 10−9
441.74 × 108<5.75 × 10−9
S. aureus 3869Sarecycline484.33 × 1082.31 × 10−9
244.33 × 1082.31 × 10−9
Vancomycin884.33 × 1082.31 × 10−9
444.33 × 1082.31 × 10−9
S. epidermidis 3703Sarecycline882.17 × 108<4.61 × 10−8
442.17 × 108<4.61 × 10−8
Vancomycin882.17 × 108<4.61 × 10−8
442.17 × 1084.61 × 10−8
S. epidermidis 3759Sarecycline283.27 × 108<3.06 × 10−8
143.27 × 108<3.06 × 10−8
Vancomycin883.27 × 108<3.06 × 10−8
443.27 × 108<3.06 × 10−8