TABLE 4

Studies evaluating eravacycline against CRAB

Reference no.β-Lactamase(s)No. of CRAB isolatesNo. of isolates with MIC >4 μg/mlMIC data (μg/ml)
MIC50MIC90Range
561630.510.12–8
59550.510.031–2
28OXA-232310.51
OXA-40170.251
OXA-58270.50.5
OXA-51a90.125–0.5
Overall286b10.51≤0.06–8
57NDM500.13–0.25
OXA-23/-40/-51/-583900.51≤0.06–2
Tigr plus OXA-23c52481.0–8.0
Overall59d20.51≤0.06–8
58OXA-23581
OXA-242
KPC1
adeB expression38e0.520.06–4
Overall158f0.51≤0.015–8
61NDM62
OXA-4827
VIM15
Overall1040.54
138OXA8
NDM4
Total140.2510.031–2
139193120.12–8
62NDM, OXA-48, VIM160.1258
60707120.06–8
140520.52≤0.016–4
  • a Hyperproduced.

  • b One isolate with OXA-23 and OXA-58, 1 isolate with NDM-1.

  • c Tigr, tigecycline resistant.

  • d Forty-nine CRAB isolates and 10 carbapenem-susceptible A. baumannii isolates.

  • e Twenty-six CRAB isolates and 12 carbapenem-susceptible A. baumannii isolates.

  • f One hundred nine CRAB isolates and 49 carbapenem-susceptible A. baumannii isolates.