TABLE 5

Activity of sarecycline and comparators against aerobic Gram-negative bacilli collected in 2015 and 2016 from patients 11 to 40 years old

Organism (phenotype)	No. of isolates	Agent	MIC (µg/ml)
Organism (phenotype)	No. of isolates	Agent	Range	50%	90%
C. freundii species complex	50	Sarecycline	2 to 256	16	128
		Tetracycline	0.25 to 256	0.5	128
		Doxycycline	0.25 to 32	1	16
		Minocycline	0.25 to 32	1	8
E. coli	80	Sarecycline	2 to >256	16	256
		Tetracycline	0.5 to >256	2	256
		Doxycycline	0.25 to 128	1	32
		Minocycline	0.25 to 64	1	8
K. pneumoniae	30	Sarecycline	2 to >256	16	256
		Tetracycline	0.5 to >256	2	256
		Doxycycline	0.5 to 128	2	32
		Minocycline	0.25 to 128	2	16
K. oxytoca	29	Sarecycline	4 to 256	16	128
		Tetracycline	0.25 to 256	0.5	128
		Doxycycline	0.25 to 16	0.5	8
		Minocycline	0.5 to 16	1	8
E. cloacae species complex	30	Sarecycline	8 to 256	32	64
		Tetracycline	1 to 256	2	8
		Doxycycline	1 to 32	2	8
		Minocycline	0.5 to 16	2	8
E. aerogenes	29	Sarecycline	1 to 128	8	16
		Tetracycline	0.5 to 16	1	4
		Doxycycline	0.5 to 16	1	8
		Minocycline	0.5 to 16	2	8
M. morganii	40	Sarecycline	64 to >256	>256	>256
		Tetracycline	1 to >256	2	128
		Doxycycline	2 to >256	8	128
		Minocycline	2 to 256	8	64
P. mirabilis	40	Sarecycline	16 to >256	>256	>256
		Tetracycline	16 to >256	32	32
		Doxycycline	16 to 64	32	64
		Minocycline	8 to 32	16	16
P. stuartii	30	Sarecycline	128 to >256	>256	>256
		Tetracycline	4 to >256	256	>256
		Doxycycline	8 to >256	256	256
		Minocycline	8 to 256	32	128
S. marcescens	40	Sarecycline	8 to 128	32	64
		Tetracycline	2 to 256	16	64
		Doxycycline	1 to 32	4	8
		Minocycline	1 to 128	2	4