TABLE 5

Activity of sarecycline and comparators against aerobic Gram-negative bacilli collected in 2015 and 2016 from patients 11 to 40 years old

Organism (phenotype)No. of isolatesAgentMIC (µg/ml)
Range50%90%
C. freundii species complex50Sarecycline2 to 25616128
Tetracycline0.25 to 2560.5128
Doxycycline0.25 to 32116
Minocycline0.25 to 3218
E. coli80Sarecycline2 to >25616256
Tetracycline0.5 to >2562256
Doxycycline0.25 to 128132
Minocycline0.25 to 6418
K. pneumoniae30Sarecycline2 to >25616256
Tetracycline0.5 to >2562256
Doxycycline0.5 to 128232
Minocycline0.25 to 128216
K. oxytoca29Sarecycline4 to 25616128
Tetracycline0.25 to 2560.5128
Doxycycline0.25 to 160.58
Minocycline0.5 to 1618
E. cloacae species complex30Sarecycline8 to 2563264
Tetracycline1 to 25628
Doxycycline1 to 3228
Minocycline0.5 to 1628
E. aerogenes29Sarecycline1 to 128816
Tetracycline0.5 to 1614
Doxycycline0.5 to 1618
Minocycline0.5 to 1628
M. morganii40Sarecycline64 to >256>256>256
Tetracycline1 to >2562128
Doxycycline2 to >2568128
Minocycline2 to 256864
P. mirabilis40Sarecycline16 to >256>256>256
Tetracycline16 to >2563232
Doxycycline16 to 643264
Minocycline8 to 321616
P. stuartii30Sarecycline128 to >256>256>256
Tetracycline4 to >256256>256
Doxycycline8 to >256256256
Minocycline8 to 25632128
S. marcescens40Sarecycline8 to 1283264
Tetracycline2 to 2561664
Doxycycline1 to 3248
Minocycline1 to 12824