Activity of sarecycline and comparators against aerobic Gram-negative bacilli collected in 2015 and 2016 from patients 11 to 40 years old
Organism (phenotype) | No. of isolates | Agent | MIC (µg/ml) | ||
---|---|---|---|---|---|
Range | 50% | 90% | |||
C. freundii species complex | 50 | Sarecycline | 2 to 256 | 16 | 128 |
Tetracycline | 0.25 to 256 | 0.5 | 128 | ||
Doxycycline | 0.25 to 32 | 1 | 16 | ||
Minocycline | 0.25 to 32 | 1 | 8 | ||
E. coli | 80 | Sarecycline | 2 to >256 | 16 | 256 |
Tetracycline | 0.5 to >256 | 2 | 256 | ||
Doxycycline | 0.25 to 128 | 1 | 32 | ||
Minocycline | 0.25 to 64 | 1 | 8 | ||
K. pneumoniae | 30 | Sarecycline | 2 to >256 | 16 | 256 |
Tetracycline | 0.5 to >256 | 2 | 256 | ||
Doxycycline | 0.5 to 128 | 2 | 32 | ||
Minocycline | 0.25 to 128 | 2 | 16 | ||
K. oxytoca | 29 | Sarecycline | 4 to 256 | 16 | 128 |
Tetracycline | 0.25 to 256 | 0.5 | 128 | ||
Doxycycline | 0.25 to 16 | 0.5 | 8 | ||
Minocycline | 0.5 to 16 | 1 | 8 | ||
E. cloacae species complex | 30 | Sarecycline | 8 to 256 | 32 | 64 |
Tetracycline | 1 to 256 | 2 | 8 | ||
Doxycycline | 1 to 32 | 2 | 8 | ||
Minocycline | 0.5 to 16 | 2 | 8 | ||
E. aerogenes | 29 | Sarecycline | 1 to 128 | 8 | 16 |
Tetracycline | 0.5 to 16 | 1 | 4 | ||
Doxycycline | 0.5 to 16 | 1 | 8 | ||
Minocycline | 0.5 to 16 | 2 | 8 | ||
M. morganii | 40 | Sarecycline | 64 to >256 | >256 | >256 |
Tetracycline | 1 to >256 | 2 | 128 | ||
Doxycycline | 2 to >256 | 8 | 128 | ||
Minocycline | 2 to 256 | 8 | 64 | ||
P. mirabilis | 40 | Sarecycline | 16 to >256 | >256 | >256 |
Tetracycline | 16 to >256 | 32 | 32 | ||
Doxycycline | 16 to 64 | 32 | 64 | ||
Minocycline | 8 to 32 | 16 | 16 | ||
P. stuartii | 30 | Sarecycline | 128 to >256 | >256 | >256 |
Tetracycline | 4 to >256 | 256 | >256 | ||
Doxycycline | 8 to >256 | 256 | 256 | ||
Minocycline | 8 to 256 | 32 | 128 | ||
S. marcescens | 40 | Sarecycline | 8 to 128 | 32 | 64 |
Tetracycline | 2 to 256 | 16 | 64 | ||
Doxycycline | 1 to 32 | 4 | 8 | ||
Minocycline | 1 to 128 | 2 | 4 |