TABLE 3

Activity of sarecycline and comparators against aerobic Gram-positive cocci

Organism (phenotype)No. of isolatesAgentMIC (µg/ml)
Range50%90%
S. aureus (methicillin susceptible)32Sarecycline0.25 to 160.50.5
Tetracycline0.25 to >320.250.5
Doxycycline0.12 to 80.120.25
Minocycline0.06 to 80.120.12
S. aureus (methicillin resistant)31Sarecycline0.25 to 40.250.5
Tetracycline0.25 to 20.250.5
Doxycycline0.12 to 20.120.25
Minocycline0.06 to 0.50.060.12
S. epidermidis (methicillin susceptible)31Sarecycline0.12 to 20.252
Tetracycline0.12 to 20.252
Doxycycline0.06 to 10.121
Minocycline0.06 to 0.250.060.25
S. epidermidis (methicillin resistant)33Sarecycline0.25 to 20.52
Tetracycline0.25 to >3212
Doxycycline0.12 to 80.51
Minocycline0.06 to 0.50.120.25
S. haemolyticus33Sarecycline0.12 to 20.122
Tetracycline0.12 to >321>32
Doxycycline0.06 to 160.516
Minocycline≤0.03 to 0.50.060.5
S. pyogenes32Sarecycline0.12 to 160.128
Tetracycline0.12 to 320.1232
Doxycycline0.06 to 80.124
Minocycline0.03 to 80.068
S. agalactiae31Sarecycline0.12 to 321616
Tetracycline0.12 to >3232>32
Doxycycline0.06 to 16816
Minocycline0.03 to 161616
E. faecalis (vancomycin susceptible)31Sarecycline0.5 to 323232
Tetracycline0.25 to >643264
Doxycycline0.12 to 1688
Minocycline0.06 to 16816
E. faecium (vancomycin resistant)30Sarecycline0.12 to 32232
Tetracycline0.12 to >642>64
Doxycycline0.06 to 1618
Minocycline≤0.03 to 160.2516
E. faecium (vancomycin susceptible)32Sarecycline0.12 to 320.532
Tetracycline0.12 to >641>64
Doxycycline0.06 to 320.516
Minocycline≤0.03 to 160.1216