TABLE 2

Pharmacological parameters associated with drug inhibition of CHIKV replication in hepatoma cells

DrugEC50 (μM)CC50 (μM)SIa
RNA levelVirus titerRNA levelVirus titer
Sofosbuvir1.0 ± 0.12.7 ± 0.5402 ± 32402149
Ribavirin2.5 ± 0.35.5 ± 1.5298 ± 2212054
Mycophenolic acid0.8 ± 0.051.1 ± 0.2370 ± 55463336
  • a SI, selectivity index (CC50/EC50).