TABLE 1

embCAB mutations and their corresponding MICs in the selected clinical isolates

pDST
Mutation(s)Susceptible (n = 43) (MICs, μg/mla)Resistant (n = 42)
embA -12c/t2 (2.5, 3.75)
embA -11c/a1 (2.5)
embA P838L1 (≤1.25)
embB N296H1 (3.75)
embB S297A + embB D1024N1
embB M306I6 (3.75 [n = 3], 5 [n = 1], ≥5b [n = 2]) 3
embB M306I + embB N296H1
embB M306I + embA -16c/a1
embB M306V1 (2.5)17
embB M306V + Q497P1
embB M306V + embA -11c/t1
embB Y319C1
embB D328G + embB L74R1 (≥5b)
embB Y334H + embA -12c/t2 (≥5b, ≥5b)
embB D354A1 (5)
embB D354A + embB D1024N1 (≥5b) 1
embB T393A1 (≤1.25)
embB G406A1 (5)4
embB G406A + embB D1024N1
embB G406D2 (≤1.25, 3.75)
embB Q497K2 (5, 5)1
embB Q497R4
embB Q497R + embB Q453A1
embB Q497R + embC A387V1
embB Q497R + embA -8c/a1
embB D1024N1 (3.75)
embC P707L1 (2.5)
No mutation18 (c)2d
  • a MICs were tested for susceptible strains only.

  • b Tested resistant when repeated.

  • c ≤1.25 (n = 11),  2.5 (n = 6), ≥5 (n = 1) (gspI -240 c/T and Rv3785 c/G at position 4,243,217).

  • d One was tested susceptible, when repeated (MIC, ≤1.25).