TABLE 1

Pharmacokinetic parametersa

Drug dose (mg once daily [mg/kg])Cmax (mg/liter)Tmax (h)AUC (h · mg/liter)
Rifampin
    600 (10.9)4,12431
    900 (16.4)3,43≥844
    1,800 (32.7)9,79≥8107
    Reference rangeb8–240.75–2
Pyrazinamide
    1,500 (27.3)24.83297
    Reference rangeb20–601–2
Ethambutol
    1,000 (18.2)1.2410
    Reference rangeb2–62–3
Moxifloxacin
    400 (7.3)1.31312
    600 (10.9)1.43417
    Reference rangeb3–51–2
Azithromycin
    250 (4.5)<0.1NDcND
  • a AUC, area under the concentration-time curve; Cmax, maximum plasma concentration; Tmax, time at which Cmax is observed.

  • b Ranges obtained from reference 4.

  • c ND, not determined.