TABLE 1

Characteristics of the populationa

CharacteristicValues for all patients (n = 21)
Demographic data
    Median (IQR) age (yr)36 (27–60)
    No. (%) of male patients17 (81)
    Median (IQR) BMI (kg/m2)26 (21–29)
No. (%) of patients admitted for:
    Trauma14 (67)
    Nontraumatic surgery7 (33)
Median (IQR) SAPS 232 (27–43)
No. (%) of patients with presumed/confirmed infection at the following site:
    Respiratory tract11 (52)
    Skin/soft tissue6 (29)
    Intra-abdominal region3 (14)
    Urinary tract1 (5)
No. (%) of patients who used vasopressors3 (14)
No. (%) of patients infected with the following pathogen:
 Enterobacteriaceae11 (52)
 Streptococcus spp.6 (29)
 Staphylococcus aureus3 (14)
 Haemophilus influenzae3 (14)
No. (%) of patients with nondocumented infection3 (14)
Median (IQR) MIC (µg/ml)0.5 (0.5–1)
No. (%) of patients receiving the following type of antimicrobial therapy:
    Association with aminoglycoside5 (24)
    Deescalation8 (38)
    Total duration of antimicrobial therapy8 (6–10)
Median (IQR) measured CLCR from day 1 to 3 (ml/min)170 (155–225)
No. (%) of patients with the following CLCR:
    CLCR < 150 ml/min3 (14)
    150 ≤ CLCR < 200 ml/min9 (43)
    CLCR ≥ 200 ml/min9 (43)
Mean (IQR) serum albumin concn from days 1 to 3 (g/liter)28 (26–32)
No. (%) of patients with therapeutic failure3 (14)
Median (IQR) MV duration (days)7 (2–11)
Median (IQR) ICU length of stay (days)12 (7–22)
  • a IQR, 25 to 75% interquartile range; BMI, body mass index; SAPS 2, simplified acute physiology score; MV, mechanical ventilation.