TABLE 2

IC50 values for MYC-053 for P. carinii and P. murina following different exposure times in the ATP assay

Drug, concn (μg/ml)% reduction in ATP/media controla
244872
P. carinii
    Ampicillin, 107.841.510
    Pentamidine, 181.1486.5886,57
    MYC-053, 5096.8197.6199.21
    MYC-053, 1068.2690.2995.58
    MYC-053, 114.9511.0826.77
    MYC-053, 0.103.2013.42
    IC503.90 ± 2.0 μg/ml2.56 ± 0.57 μg/ml1.61 ± 1.72 μg/ml
P. murina
    Ampicillin, 102.860.260
    Pentamidine, 192.0797.7098.12
    MYC-053, 5097.8498.8998.77
    MYC-053, 1076.5698.5197.92
    MYC-053, 11.08242.1194.42
    MYC-053, 0.10027.82
    IC503.30 ± 0.19 μg/ml1.50 ± 0.13 μg/ml0.165 ± 0.06 μg/ml
  • a Results represent the means from the 3 experiments which each contained three technical replicates.