Physical characteristics of nanoparticle formulationsa
Formulation | Mean particle size (nm) ± SD | Mean ZP (mV) ± SD | PDI | Mean LC% ± SD | Mean EE% ± SD |
---|---|---|---|---|---|
NPs | 227.1 ± 5.06 | −1.84 ± 0.25 | 0.223 | ||
AmB-NPs | 287.8 ± 8.64 | −10.9 ± 1.9 | 0.205 | 5.7 ± 0.12 | 85 ± 2.4 |
↵a NPs, plain PLGA nanoparticles; AmB-NPs, amphotericin B-loaded PLGA nanoparticles; ZP, zeta potential; PDI, polydispersity index; LC, loading content; EE, entrapment efficiency.