TABLE 2

COMSTAT analysis of structural parameters of C. albicans biofilm in different treatmentsa

GroupMean thickness (μm) ± SDAvg diffusion distance (μm) ± SDMean textural entropy ± SDMean areal porosity ± SD
Control30.56 ± 0.6210.94 ± 0.184.40 ± 0.190.553 ± 0.037
US29.38 ± 0.568.27 ± 0.15**3.77 ± 0.120.697 ± 0.021
AmB25.69 ± 0.13**4.21 ± 0.03**3.15 ± 0.07**0.757 ± 0.023**
US + AmB20.51 ± 0.65**2.82 ± 0.14**2.22 ± 0.03**0.897 ± 0.032**
AmB-NPs26.72 ± 0.24**4.53 ± 0.11**3.17 ± 0.06**0.797 ± 0.015**
US + AmB-NPs11.56 ± 1.22**Δ1.55 ± 0.11**Δ1.60 ± 0.09**Δ1.173 ± 0.067**Δ
  • a **, P < 0.01 compared to the control group; Δ, P < 0.01 compared to the AmB group. US, ultrasound; AmB, amphotericin B; AmB-NPs, amphotericin B-loaded PLGA nanoparticles.