TABLE 1

Susceptibility and MIC and IC50 values of MYC-053 and other antifungal agents against C. glabrata and C. auris

Fungal speciesIsolate no.Susceptibility toa:IC50 and MIC data by drug (μg/ml)b
MYC-053FLCCAS
FLCCASIC50MICIC50MICIC50MIC
C. glabrataATCC 90030SS0.54140.251
CG1INA0.5464
CG2SNA0.540.5
CG3INA0.25464
CG4SNA0.524
CG5SNA0.522
CG6INA0.5232
CG7INA0.125264
CG8INA0.5432
CG9INA0.5264
CG10RNA0.54>64
MR-V32RS0.252>64>640.250.5
MR-V35RR0.54>64>6444
MR-V51RI0.52>64>640.52
MR-V16RR0.1251>64>6448
MR-V18RI0.52>64>640.52
MR-V19RR0.54>64>6422
SS-V120II0.528320.51
SS-V114SS0.252280.1250.25
SS-V10SR0.2522422
C. aurisCAU1SNA142
CAU2SNA440.5
CAU3RNA44>64
V-2016-1RR24>64>6422
V-2016-2RI14>64>640.52
C. neoformansATCC 90030SNA1214
CN1RNA128
CN2SNA121
CN3RNA114
CN4RNA1264
CN5RNA244
CN6RNA2264
CN7RNA244
CN8SNA242
CN9SNA222
CN10SNA121
RR-94RNA0.5264>64
RR-112RNA228>64
RR-1025RNA0.5164>64
HR-30RNA2232>64
HR-02RNA1128
SS-18RNA242>64
SS-10SNA1118
  • a Candida spp. were considered susceptible (S) to FLC at an MIC of ≤8 μg/ml, intermediate (I) at an MIC of 8 to 64 μg/ml, and resistant (R) at an MIC of ≥64 μg/ml (5052). Candida spp. were considered susceptible to CAS at an MIC of ≤0.25 μg/ml, intermediate at an MIC of 0.5 μg/ml, and resistant at an MIC of ≥1 μg/ml (35). Only potential breakpoints for FLC against C. neoformans were used, as follows: susceptible, ≤2 mg/liter; resistant, >2 mg/liter. NA, not available.

  • b –, not tested.