Unadjusted and adjusted effects of ICU status on susceptibilitya

Effect and antibioticSingle agentFQ combinationAG combination
Unadjusted effects for non-ICU vs ICU status
GLMM-adjusted effectsb for non-ICU vs ICU status
  • a Numbers indicate the effect size of non-ICU status; i.e., an odds ratio of 1.12 for single-agent ESC indicates that the odds of a P. aeruginosa isolate being susceptible to ESC is 12% higher for non-ICU isolates than for ICU isolates. Abbreviations: AG, aminoglycoside (gentamicin, tobramycin, amikacin); Carb, carbapenem (imipenem, meropenem); CI, confidence interval; ESC, extended-spectrum cephalosporins (ceftazidime, cefepime); FQ, fluoroquinolone (ciprofloxacin, levofloxacin); GLMM, generalized linear mixed models; ICU, intensive care unit; NA, not applicable; OR, odds ratio; TZP, piperacillin-tazobactam.

  • b Effects were adjusted using GLMM. Adjusting variables include source (blood/respiratory), onset (admission/hospital), and hospital characteristics (teaching status, bed size, urban/rural, geographic region).