TABLE 1

MIC range, geometric mean, MIC mode, MIC50, and MIC90 of diacerein and its metabolite rhein against 65 common clinical ocular Gram-positive bacterial isolates

Antibacterial agent by bacterial species (n)MIC (μg/ml)a
RangeGMModeMIC50MIC90
Staphylococcus epidermidis (38)
    Diacerein1–166.54b,c8816
    Rhein2–168.61b,c8816
    Levofloxacin0.125–160.750.50.54.40
    Amikacin0.25–161.440.51.508
Staphylococcus aureus (7)
    Diacerein4–3211.89b8832
    Rhein4–168.83b16816
    Levofloxacin0.125–20.410.250.252
    Amikacin0.25–162.691416
Staphylococcus intermedius (6)
    Diacerein4–168b8816
    Rhein8–3212.70b81232
    Levofloxacin0.125–0.50.220.250.250.5
    Amikacin0.25–161.590.251.516
Enterococcus spp. (3)
    Diacerein8–3220.16323232
    Rhein8–321681632
    Levofloxacin0.25–40.630.250.254
    Amikacin0.5–83.17888
Streptococcus sanguinis (8)
    Diacerein32–12869.79b6464128
    Rhein64–12876.11b6464128
    Levofloxacin0.25–80.840.50.758
    Amikacin0.125–12829.34b128128128
Streptococcus pneumoniae (3)
    Diacerein64–128101.59128128128
    Rhein64–128101.59128128128
    Levofloxacin0.5–10.630.50.51
    Amikacin1–12812.70116128
  • a All MICs were determined visually; the MIC50 and MIC90 values represent the concentrations required to inhibit 50% and 90% of the tested strains. GM, geometric mean.

  • b P < 0.05 compared with levofloxacin.

  • c P < 0.05 compared with amikacin; analyzed using one-way ANOVA.