TABLE 2

MICs of M. tuberculosis inhA promoter and coding sequence mutantsa

StrainSourceSNPsLiquid MIC (μM) of agent:
fabG1-inhA promoter (nt)InhARifampinIsoniazidAN12855
ErdmanParentnana0.010.440.16
ED-DPR18-RM4in vivoNo SNPG96V0.0070.83>20 (>122)b
ED-DPR18-RM1in vitroNo SNPG96A0.0180.4414.2 (87)b
ED-DPR19-RM2in vitroC-15TNo SNP0.023.2 (7)b1.1 (7)b
  • a nt, nucleotide; na, not applicable; SNP, single nucleotide polymorphism; No SNP, no single nucleotide polymorphism.

  • b Calculated as ∼fold shift versus Erdman.