TABLE 2

CVVHDF parameters

ParameterData by patient
1234
Dialysate (ml/h)1,5001,000550650
Pre-filter replacement (ml/h)500450500600
Post-filter replacement (ml/h)50505050
Blood flow (ml/min)904070100
Blood flow (ml/kg/min)96.7134
Normalized effluent rate (ml/1.73 m2/h)8,7508,5936,0893,076
Effluent urea/BUN ratioa0.750.750.750.77
Delivered CVVHDF clearance (ml/1.73 m2/h)b6,5636,4454,5672,369
Circuit age (h)c22.633.815.211.2
  • a BUN, blood urea nitrogen.

  • b Delivered CVVHDF clearance = normalized effluent rate × BUN/effluent urea nitrogen ratio.

  • c Measured from circuit change to time of cefepime dose prior to sampling.