Parameter | Value |
---|---|

C_{max} (ng/ml) | 9,986 (7,813–14,504) |

t_{max} (h) | 2 (1–24) |

AUC_{0–∞} (ng·h/ml) | 1,807,590 (1,598,235–2,049,829) |

AUC_{0–last} (ng·h/ml) | 1,544,339 (1,354,506–1,854,997) |

t_{1/2} (h) | 140 (106–164) |

↵a The data represent the geometric mean (range) for all parameters except

*t*_{max}, for which the data represent the median (range). Participants (*n*= 8) were treated with a single dose of DSM265 on day 7. The data included in the PK analysis encompass time points from the day of treatment until the day of second dose administration. Abbreviations: AUC_{0–last}, the area under the concentration-time curve from 0 h up to the last time point measure; AUC_{0–∞}, area under the concentration-time curve from 0 h extrapolated to infinity;*t*_{1/2}, elimination half-life;*C*_{max}, maximum plasma concentration;*t*_{max}, the time point when*C*_{max}was reached;*t*_{1/2}, elimination half-life.