TABLE 1

Efficacy and drug resistance of AN12855 and isoniazid in the C3HeB/FeJ mouse model

GroupTime point sampled
Start of treatment2 weeks4 weeks8 weeks
Lung efficacy [mean ± SEM, n]
    Vehicle only7.61 ± 0.18, 8/87.91 ± 0.24, 7/77.40 ± 0.33, 7/7nda
    Isoniazid (25 mg/kg)6.90 ± 0.29, 8/86.67 ± 0.27, 7/76.63 ± 0.53, 7/7
    AN12855 (100 mg/kg)6.36 ± 0.24, 8/86.13 ± 0.23, 8/86.27 ± 0.11, 8/8
Drug resistance [mean ± SEM, (range), n, % resistance]
    Isoniazid[≤2.63 ± 0.09, (<2.40–3.00), 6/8, 0.001][≤3.10 ± 0.21, (<2.40–3.89), 6/8, 0.016][5.56 ± 0.43, (3.24–6.64), 7/7, 8][6.09 ± 0.49, (3.77–7.71), 7/7, 29]
    AN12855[<2.40 ± 0.00, (<2.40), 0/8, <0.0006][<2.40 ± 0.00, (<2.40), 0/8, <0.011][<2.40 ± 0.00, (<2.40), 0/8, <0.019][≤2.83 ± 0.43, (<2.40–5.44), 1/8, 0.037]
  • a nd, not done.