TABLE 3

Multivariate analysis of independent predictors of acute kidney injury in the combined populationa

CovariateOdds ratio95% CI
Vancomycin plus piperacillin-tazobactam2.1611.620–2.883
Baseline CrCl ≤ 60 ml/min2.2201.791–2.751
Vasopressor use1.8771.512–2.329
Initial vancomycin trough > 20 μg1.6801.281–2.205
Charlson comorbidity index1.0511.012–1.091
  • a Variables included in model: use of piperacillin-tazobactam, cefepime, or meropenem; baseline creatinine clearance below 60 ml/min; use of one or more vasopressor agent; admission to SICU; Charlson comorbidity index; initial vancomycin trough value of >20. Backwards logistic regression was used for multivariate analysis (Hosmer and Lemeshow test value = 0.569).