TABLE 1

Susceptibility testing resultsa

TABLE 1
  • a All bla genes were expressed from pBC SK(+/−) in E. coli DH10B, except blaOXA-1, which was expressed from plasmid RGN238. Test results (MICs) are in μg/ml. The concentrations of β-lactams were varied, while the BLIs AAI101 and tazobactam were held at the fixed concentrations listed. Susceptibility is based on CLSI 2018 β-lactam breakpoints (40) and is shown as follows: green, susceptible; yellow, intermediate or susceptible-dose dependent; red, resistant. Abbreviations: FEP, cefepime; PIP, piperacillin; TZP, piperacillin-tazobactam; IPM, imipenem; MEM, meropenem; ESBL, extended-spectrum β-lactamase; IR, inhibitor (clavulanic acid) resistant.