TABLE 6

Quantification of cefepime and AAI101 in mouse plasma following subcutaneous coadministration

Sampling time (h)Mean value (μg/ml) ± SD with Bessel’s correctionRatio of mean values for cefepime-AAI101
CefepimeAAI101
0.2570.62 ± 4.8011.55 ± 1.816.1
0.585.50 ± 10.0312.63 ± 1.136.8
158.26 ± 9.708.42 ± 2.386.9
23.81 ± 3.271.20 ± 0.893.2
34.18 ± 4.661.25 ± 1.063.3
42.03 ± 2.810.89 ± 1.062.3
60.35 ± 0.270.32 ± 0.212.2
80.14 ± 0.070.17 ± 0.060.8