TABLE 3

The PK/PD breakpoints, Cmax, and AUC0–24h for the simulated dosage regimens

Dosage regimenbPK/PD breakpointa(mg/liter)Mean (SD)
T>MIC ≥ 30%T>MIC ≥ 64%Cmax (mg/liter)AUC0–24h (mg · h/liter)
250-mg dose
    Once daily4416.4 (4.3)259.5 (97.9)
    Twice daily8826.4 (8.0)516.7 (188.3)
    Three times daily161635.5 (10.4)737.7 (239.1)
    Four times daily161644.4 (12.5)945.1 (279.8)
500-mg dose
    Once daily8832.7 (8.6)519.0 (195.7)
    Twice daily161652.9 (16.0)1,033.4 (376.7)
    Three times daily323271.0 (20.7)1,475.4 (478.3)
    Four times daily484888.8 (24.9)1,890.1 (559.6)
750-mg dose
    Split to 250/500 mg (a.m./p.m.)161642.2 (11.7)763.8 (271.0)
    Once daily16849.6 (13.2)789.5 (304.6)
    Twice daily323278.4 (22.9)1,527.5 (537.3)
    Three times daily6448106.5 (30.6)2,215.0 (702.6)
  • a PK/PD breakpoint defined as the highest MIC where at least 90% of the PTA was achieved. PK/PD, pharmacokinetic(s)/pharmacodynamic(s).

  • b AUC0–24h, area under the drug concentration-time curve from time 0 to 24 hours; Cmax, maximum (peak) concentration; PTA, probability of target attainment; T>MIC, time above the MIC.