TABLE 8

Resistance frequencies of the test strains used in the animal model

StrainNo. of colonies showing breakthrough growth (CFUs)
CefepimeCefepime + 4 μg/ml AAI101Cefepime + 8 μg/ml AAI101Meropenem
E. coli ATCC 25922<1.0 × 10−9<1.0 × 10−9<1.0 × 10−9<1.0 × 10−9
K. pneumoniae R-43<2.0 × 10−9<2.0 × 10−9<2.0 × 10−91.6 × 10−7
K. pneumoniae B-124<3.0 × 10−9<3.0 × 10−9<3.0 × 10−93.2 × 10−7
E. cloacae B-143<5.6 × 10−9<5.6 × 10−9<5.6 × 10−9<5.6 × 10−9