TABLE 3

Relevant laboratory and treatment dataa

MetricbValues by treatment type:
Combination therapyMonotherapy
Vancomycin MIC (mg/liter), n (%)
    0.55 (29)3 (9)
    112 (71)20 (91)
    20 (0)0 (0)
Blood analyses, median (IQR)
    WBC (×1,000/mm3)17.3 (13.7, 22.6)14.2 (9.7, 18.5)
    Platelet (×1,000/mm3)246 (144, 384)173 (98, 323)
    CrCl (ml/min)74 (24, 119)47 (16, 114)
    Procalcitonin (ng/ml)0.22 (0.07, 0.74)0.72 (0.52, 8.8)
    CRP (mg/liter)127 (109, 212)176 (108, 236)
    IL-10 (pg/ml)9.5 (5, 20.5)7 (5.5, 20.5)
Treatment
    Vancomycin trough (initial, mg/liter)N/Ac16.2 (10.7, 19.8)
    Daptomycin dose (median, mg/kg)8.68.0
  • a P values are >0.05 for all comparisons.

  • b IQR, interquartile range; WBC, white blood cell; CRP, C-reactive protein.

  • c Values were obtained for only 3 patients prior to randomization with initial trough values (mg/liter), namely, 27, 19, and 9. N/A, not available.