TABLE 1

Demographic data for subjects included in the population pharmacokinetic model

CharacteristicaMedian (IQR) or no. (%) for:
Healthy subjects (n = 12)Patients (n = 235)
Age (yrs)36.1 (27.9–43.9)41.0 (29.0–52.7)
Sex, male6 (50.0)179 (76.2)
Wt (kg)77.3 (74.9–83.2)58.0 (50.6–67.0)
BMI (kg/m2)25.7 (23.0–28.2)20.4 (18.4–22.9)
Patient diagnosis
    NTM14 (6.0)
    DS-TB16 (6.8)
    RR/MDR-TB160 (68.1)
    Pre-XDR-TB36 (15.3)
    XDR-TB9 (3.8)
SrCr (mg/dl)0.90 (0.73–1.00)0.90 (0.70–1.03)
CrCL (ml/min)108.8 (98.9–139.9)89.1 (68.8–111.9)
  • a BMI, body mass index; CrCL, creatinine clearance; DS, drug susceptible; NTM, nontuberculous mycobacteria; pre-XDR, preextensively drug-resistant; RR/MDR, rifampin resistant/multidrug resistant; SrCr, serum creatinine; TB, tuberculosis; XDR, extensively drug-resistant.