TABLE 1

Plasma PK/PD parameters in TB patients receiving the WHO-recommended doses of MXF, LVX, or GTX

DrugDose
(mg/day)
MIC90
(mg/liter)a
MBC
(mg/liter)b
AUC[0–24]
(mg*h/liter)a
median (SD)
fAUC[0–24]
range
(mg*h/liter)c
fAUC/MIC
rangec
fAUC/MBC
range
(mg*h/liter)c
Moxifloxacin4000.50.357 (12)23–4346–8677–143
Levofloxacin1,0001.00.9129 (106)74–25874–25882–287
Gatifloxacin4000.50.540 (7)22–3944–7844–78
  • a Data are from reference 19.

  • b Data are from reference 47.

  • c Data were computed using MIC90 values from reference 19, MBC values from reference 47, and average human plasma protein binding values obtained as part of this work (Table S2).