TABLE 3

BLI inhibitory efficienciesa

β-LactamaseMean k2/K (M−1 s−1) ± SD (referenceb)
AAI101TazobactamAvibactam
SHV-12.3 ± 0.2 × 1053.9 ± 0.4 × 1056.0 ± 0.6 × 104 (41)
CTX-M-151.9 ± 0.2 × 1052.2 ± 0.2 × 1053.3 ± 0.3 × 105
KPC-21.7 ± 0.2 × 1042.5 ± 0.2 × 103 (34)2.2 ± 0.2 × 104 (42)
  • a For nonsaturating plots in Fig. 2, k2/K values are presented; however, for saturating plots in Fig. 2, kinact/KI values are presented.

  • b Where a reference is cited, the data were obtained from that reference.