TABLE 3

PK parameters estimated by using all data or specific data

ParameteraPK values [median (range)] for:
All data (n = 46)Day 2 (n = 46)Day 5 (n = 37)Day 10 (n = 21)
Cmax (mg/liter)5.1 (1.1–8.8)5.6 (3.6–9.0)5.3 (3.6–9.4)
Cmin (mg/liter)1.1 (0.5–2.3)1.2 (0.5–2.7)1.1 (0.5–2.6)
AUC0-24 (mg·h/liter)59.6 (32.7–105)61.1 (32.8–108)57.8 (44.0–113)58.4 (37.2–105)
CL (liters/h)0.87 (0.47–1.70)0.84 (0.46–1.78)0.88 (0.44–1.58)0.90 (0.47–1.88)
V1 (liters)11.2 (6.7–26.4)11.2 (6.7–26.4)11.9 (7.5–20.1)11.2 (7.7–19.4)
V2 (liters)6.9 (1.6–22)6.9 (2.6–13)5.3 (1.5–7.1)5.5 (3.3–6.6)
k10 (/h)0.074 (0.047–0.11)0.072 (0.048–0.11)0.079 (0.054–0.12)0.077 (0.061–0.12)
  • a Cmax, maximal concentration; Cmin, minimal concentration; AUC0–24, area under the concentration-time curve from 0 to 24 h; CL, clearance; V1, central volume of distribution; V2, peripheral volume of distribution; k10, elimination rate constant from V1 at equilibrium between V1 and V2. Shrinkage (%): all data, CL of 11.2, V1 of 9.3, and V2 of 33.7; day 2, CL of 2.6, V1 of 4.6, and V2 of 54.0; day 5, CL of 17.6, V1 of 28.9, and V2 of 63; day 10, CL of 11.5, V1 of 42.1, and V2 of 76.7.