Parameter^{a} | PK values [median (range)] for: | |||
---|---|---|---|---|

All data (n = 46) | Day 2 (n = 46) | Day 5 (n = 37) | Day 10 (n = 21) | |

C_{max} (mg/liter) | 5.1 (1.1–8.8) | 5.6 (3.6–9.0) | 5.3 (3.6–9.4) | |

C_{min} (mg/liter) | 1.1 (0.5–2.3) | 1.2 (0.5–2.7) | 1.1 (0.5–2.6) | |

AUC_{0-24} (mg·h/liter) | 59.6 (32.7–105) | 61.1 (32.8–108) | 57.8 (44.0–113) | 58.4 (37.2–105) |

CL (liters/h) | 0.87 (0.47–1.70) | 0.84 (0.46–1.78) | 0.88 (0.44–1.58) | 0.90 (0.47–1.88) |

V_{1} (liters) | 11.2 (6.7–26.4) | 11.2 (6.7–26.4) | 11.9 (7.5–20.1) | 11.2 (7.7–19.4) |

V_{2} (liters) | 6.9 (1.6–22) | 6.9 (2.6–13) | 5.3 (1.5–7.1) | 5.5 (3.3–6.6) |

k_{10} (/h) | 0.074 (0.047–0.11) | 0.072 (0.048–0.11) | 0.079 (0.054–0.12) | 0.077 (0.061–0.12) |

↵a

*C*_{max}, maximal concentration;*C*_{min}, minimal concentration; AUC_{0–24}, area under the concentration-time curve from 0 to 24 h; CL, clearance;*V*_{1}, central volume of distribution;*V*_{2}, peripheral volume of distribution;*k*_{10}, elimination rate constant from*V*_{1}at equilibrium between*V*_{1}and*V*_{2}. Shrinkage (%): all data, CL of 11.2,*V*_{1}of 9.3, and*V*_{2}of 33.7; day 2, CL of 2.6,*V*_{1}of 4.6, and*V*_{2}of 54.0; day 5, CL of 17.6,*V*_{1}of 28.9, and*V*_{2}of 63; day 10, CL of 11.5,*V*_{1}of 42.1, and*V*_{2}of 76.7.