TABLE 4

Correlation coefficients between PK parameters and Child-Pugh score, plasma bilirubin, albumin, INR, and SOFA score on day 5a (n = 37)

ParameterAUC0-24CLV1k10
C-P score0.03−0.070.19−0.50**
Bilirubin0.000.020.22−0.46**
Albumin0.45**−0.31−0.15−0.34*
INR−0.080.00−0.03−0.04
SOFA score0.03−0.050.20−0.47**
  • a C-P, Child-Pugh; INR, international normalized ratio; SOFA, sequential organ failure assessment; AUC0–24, area under the concentration-time curve from 0 to 24 h; V1, central volume of distribution; V2, peripheral volume of distribution; k10, the elimination rate constant from V1 at equilibrium between V1 and V2. *, P < 0.05. **, P < 0.01.