TABLE 1

Activity of MenA inhibitors against M. tuberculosis

CompoundMIC (μM)a
H37RvLPH37RvMAH37RvMA ΔcydC::aph
NM-141 ± 255 ± 438 ± 3
NM-242 ± 249 ± 243 ± 4
NM-314 ± 0.215 ± 0.215 ± 2
NM-44.5 ± 0.75.5 ± 1.73.8 ± 0.2
  • a MenA inhibitors were tested against M. tuberculosis. MICs were calculated as the minimum concentrations required to inhibit the growth of M. tuberculosis by 90%, as determined by Levenberg-Marquardt least-squares plots. Data are the mean ± standard deviation of two independent experiments.