Parameter | Pyrazinamide | Ethambutol | ||
---|---|---|---|---|

Estimated value | Relative SE (%) | Estimated value | Relative SE (%) | |

CL (liters/h)^{a} | 2.97 | 3 | 35.6 | 20 |

V (liters)^{a} | 33.0 | 3 | 80.5 | 17 |

K (h)_{a} | 3.04 | 9 | 0.454 | 11 |

V (liters)_{p}^{a}^{,}^{b} | 649 | 110 | ||

Q^{a}^{,}^{b} | 43.7 | 32 | ||

T_{lag} (l/h) | 0.419 | 12 | 0.81 | 6 |

F | 1 (fixed) | 1 (fixed) | ||

Proportional error (%) | 0.05 | 18 | 31.7 | 4 |

Additive error (mg/liter) | 2.49 | 12 | 0.25 (fixed)^{d} | |

Between-subject variability of CL^{c} (%CV) | 30.1 | 7 | 33.9 | 17 |

Between-subject variability of V (%CV)_{c} | 15.1 | 11 | 77.2 | 12 |

Between-occasion variability of K_{a}^{c} (%CV) | 64.2 | 7 | 36.7 | 26 |

Between-occasion variability of T_{lag}^{c} (%CV) | 66.7 | 12 | 22.8 | 32 |

Between-occasion variability of F^{c} (%CV) | 16.7 | 4 | 30.6 | 9 |

↵a Allometric scaling was used for CL,

*V*,_{c}*Q*, and*V*, and values are reported for the median weight of the cohort (52 kg)._{p}↵b

*Q*and*V*were estimated using Bayesian priors, with typical values of 64.4 liters/h and 420.7 liters, respectively, from a previous study (7), with 50% uncertainty._{p}↵c The between-subject and between-occasion variability values were assumed to be log-normally distributed and are reported as approximate coefficients of variation (%CV).

↵d The estimate of the additive error was approximating zero and was therefore fixed to half the value of the lowest limit of quantification (0.5 mg/liter).