TABLE 3

Activities of cefepime-enmetazobactam and comparator agents tested against clinical Gram-negative isolates

Species (n), drug, and regionMIC (μg/ml)% susceptible
MIC50MIC90RangeCLSIEUCAST
Enterobacteriaceae
    All (1,696)
        Cefepime0.06320.015 to >6483.782.5
        Cefepime-enmetazobactam0.060.250.015 to >64NAcNA
        Piperacillin-tazobactam2640.12 to >12885.782.0
        Meropenem0.030.060.008 to >896.296.4
        Ceftolozane-tazobactam0.2520.06 to >3290.788.5
        Ceftazidime0.25640.03 to >6481.277.7
        Ceftazidime-avibactam0.120.5≤0.015 to >6499.799.7
        Gentamicin0.5160.12 to >3289.088.3
        Ciprofloxacin0.03>160.004 to >1671.771.7
    United States (848)
        Cefepime0.0640.015 to >6488.687.9
        Cefepime-enmetazobactam0.060.250.015 to >64NANA
        Piperacillin-tazobactam2320.12 to >12889.586.2
        Meropenem0.030.030.008 to >897.897.8
        Ceftolozane-tazobactam0.2510.06 to >3293.891.4
        Ceftazidime0.25320.03 to >6486.183.4
        Ceftazidime-avibactam0.120.25≤0.015 to 1699.999.9
        Gentamicin0.520.12 to >3290.990.3
        Ciprofloxacin0.03>160.004 to >1675.475.4
    Europe (848)
        Cefepime0.06>640.015 to >6478.977.1
        Cefepime-enmetazobactam0.060.250.015 to >64NANA
        Piperacillin-tazobactam2>1280.25 to >12881.877.8
        Meropenem0.030.060.008 to >894.795.0
        Ceftolozane-tazobactam0.2540.06 to >3287.685.6
        Ceftazidime0.25640.06 to >6476.371.9
        Ceftazidime-avibactam0.120.5≤0.015 to >6499.599.5
        Gentamicin0.5320.12 to >3287.186.3
        Ciprofloxacin0.03>160.004 to >1668.068.0
    E. coli (697)
        Cefepime0.06160.015 to >6485.884.4
        Cefepime-enmetazobactam0.060.120.015 to 32NANA
        Piperacillin-tazobactam28≤0.12 to >12892.490.5
        Meropenem0.0150.030.008 to 899.699.7
        Ceftolozane-tazobactam0.250.50.06 to >3298.196.8
        Ceftazidime0.25160.06 to >6486.782.2
        Ceftazidime-avibactam0.120.25≤0.015 to 2100100
        Gentamicin0.5320.12 to >3286.285.5
        Ciprofloxacin0.015>160.004 to >1664.164.1
    E. coli ESBL genotypea (109)
        Cefepime16>640.12 to >6413.86.4
        Cefepime-enmetazobactam0.060.120.016 to 32NANA
        Piperacillin-tazobactam4640.5 to >12882.675.2
        Meropenem0.030.030.008 to 899.199.1
        Ceftolozane-tazobactam0.520.12 to >3293.688.1
        Ceftazidime16641 to >6426.63.7
        Ceftazidime-avibactam0.120.25≤0.015 to 2100100
        Gentamicin1>320.12 to >3259.658.7
        Ciprofloxacin>16>160.008 to >169.29.2
    K. pneumoniae (799)
        Cefepime0.06>640.015 to >6480.980.6
        Cefepime-enmetazobactam0.060.50.015 to >64NANA
        Piperacillin-tazobactam4>1280.25 to >12883.178.6
        Meropenem0.030.120.008 to >892.792.9
        Ceftolozane-tazobactam0.2580.06 to >3287.585.7
        Ceftazidime0.25>640.03 to >6480.478.1
        Ceftazidime-avibactam0.120.5≤0.015 to >6499.699.6
        Gentamicin0.2580.12 to >3290.089.1
        Ciprofloxacin0.03>160.004 to >1675.275.2
    K. pneumoniae ESBL genotypea (102)
        Cefepime64>641 to >643.92.0
        Cefepime-enmetazobactam0.1210.03 to 8NANA
        Piperacillin-tazobactam32>1281 to >12844.128.4
        Meropenem0.0310.016 to >892.291.2
        Ceftolozane-tazobactam2320.12 to >3252.947.1
        Ceftazidime64>640.25 to >644.92.0
        Ceftazidime-avibactam0.251≤0.015 to 2100100
        Gentamicin32>320.25 to >3241.238.2
        Ciprofloxacin>16>160.008 to >167.87.8
    K. pneumoniae KPC genotypeb (45)
        Cefepime>64>648 to >640.00.0
        Cefepime-enmetazobactam16>640.5 to >64NANA
        Piperacillin-tazobactam>128>1281 to >1282.22.2
        Meropenem>8>84 to >80.00.0
        Ceftolozane-tazobactam>32>3216 to >320.00.0
        Ceftazidime>64>6432 to >640.00.0
        Ceftazidime-avibactam140.03 to >1697.897.8
        Gentamicin2>320.12 to >3271.166.7
        Ciprofloxacin>16>160.5 to >160.00.0
    E. aerogenes (100)
        Cefepime0.060.50.015 to 897.096.0
        Cefepime-enmetazobactam0.060.250.015 to 2NANA
        Piperacillin-tazobactam2640.25 to 12877.069.0
        Meropenem0.030.120.015 to 1100100
        Ceftolozane-tazobactam0.2540.06 to 3284.076.0
        Ceftazidime0.25640.06 to >6473.065.0
        Ceftazidime-avibactam0.120.5≤0.015 to 4100100
        Gentamicin0.50.50.12 to >3298.098.0
        Ciprofloxacin0.0150.120.004 to >1691.091.0
    E. cloacae (100)
        Cefepime0.12160.03 to >6479.071.0
        Cefepime-enmetazobactam0.1210.03 to >64NANA
        Piperacillin-tazobactam41281 to >12868.063.0
        Meropenem0.030.120.008 to >897.098.0
        Ceftolozane-tazobactam0.5160.25 to >3271.065.0
        Ceftazidime0.5>640.12 to >6458.055.0
        Ceftazidime-avibactam0.250.50.03 to >6498.098.0
        Gentamicin0.250.50.12 to >3292.092.0
        Ciprofloxacin0.0320.008 to >1677.077.0
P. aeruginosa (297)
        Cefepime4160.12 to >6479.579.5
        Cefepime-enmetazobactam4160.12 to >64NANA
        Piperacillin-tazobactam81280.12 to >12875.475.4
        Meropenem0.5>80.015 to >876.476.4
        Ceftolozane-tazobactam0.540.25 to >3292.692.6
        Ceftazidime4640.25 to >6478.578.5
        Ceftazidime-avibactam280.06 to >6495.095.0
        Gentamicin2320.12 to >3284.584.5
        Ciprofloxacin0.25160.004 to >1668.068.0
    United States (149)
        Cefepime4160.5 to >6482.682.6
        Cefepime-enmetazobactam4160.12 to >64NANA
        Piperacillin-tazobactam4640.12 to >12881.281.2
        Meropenem0.580.015 to >875.275.2
        Ceftolozane-tazobactam0.520.25 to >3298.098.0
        Ceftazidime4160.5 to 6487.287.2
        Ceftazidime-avibactam240.25 to >6498.798.7
        Gentamicin280.12 to >3289.389.3
        Ciprofloxacin0.1280.03 to >1673.273.2
    Europe (148)
        Cefepime4320.12 to >6476.476.4
        Cefepime-enmetazobactam4320.12 to >64NANA
        Piperacillin-tazobactam8>1280.25 to >12869.969.9
        Meropenem0.5>80.03 to >877.777.7
        Ceftolozane-tazobactam0.580.25 to >3287.287.2
        Ceftazidime4640.25 to >6469.669.6
        Ceftazidime-avibactam280.06 to >6491.291.2
        Gentamicin2>320.12 to >3279.679.6
        Ciprofloxacin0.25>160.004 to >1662.862.8
  • a Isolates containing genes encoding an ESBL with or without OXA-48 or AmpC β-lactamases.

  • b Isolates containing genes encoding a KPC with or without an ESBL, OXA-48, and/or AmpC β-lactamases.

  • c NA, not applicable.