TABLE 2

Cumulative percentage MIC distribution and ECOFF values of cefepime and cefepime-enmetazobactam against Gram-negative pathogens collected worldwide in the United States and Europe during 2014 and 2015

Species (n) and drugCumulative % isolates at or below various MICs (μg/ml)aECOFF (μg/ml)
0.0150.030.060.120.250.51248163264>64
Enterobacteriaceae
    All (1,696)
    Cefepime2.730.262.972.978.281.182.583.785.387.089.291.593.6100
    Cefepime-enmetazobactam2.739.677.187.792.694.896.296.897.398.198.599.099.4100
E. coli (697)
    Cefepime2.327.364.375.580.983.284.485.887.889.892.394.797.11000.12
    Cefepime-enmetazobactam3.644.086.195.098.999.399.799.999.999.999.9100
E. coli ESBL genotypeb (109)
    Cefepime0.90.93.76.413.823.936.752.367.081.7100
    Cefepime-enmetazobactam0.919.369.790.898.298.299.199.199.199.199.1100
K. pneumoniae (799)
    Cefepime3.135.265.173.577.579.580.680.981.282.785.087.690.01000.12
    Cefepime-enmetazobactam2.340.376.285.089.492.493.293.795.096.497.298.199.0100
K. pneumoniae ESBL genotypeb (102)
    Cefepime2.03.96.916.730.442.252.9100
    Cefepime-enmetazobactam8.842.266.777.589.292.293.198.0100
    Cefepime-tazobactam1.08.832.449.060.868.676.585.388.292.295.196.197.1100
K. pneumoniae KPC genotypec (45)
    Cefepime2.211.128.946.7100
    Cefepime-enmetazobactam4.46.713.324.442.257.871.186.7100
E. aerogenes (100)
    Cefepime5.035.062.069.081.091.096.097.099.01000.12
    Cefepime-enmetazobactam2.035.064.084.094.097.099.0100
E. cloacae (100)
    Cefepime7.037.055.062.069.071.079.086.088.090.091.091.01000.25
    Cefepime-enmetazobactam7.034.063.074.081.092.096.096.097.098.098.098.0100
P. aeruginosa (297)
    Cefepime0.31.32.712.145.164.379.592.395.698.310016
    Cefepime-enmetazobactam0.71.02.012.144.867.382.893.696.398.3100
  • a MIC90 values are in boldface.

  • b Isolates containing an ESBL gene with or without OXA-48 and/or AmpC genes.

  • c Isolates containing a KPC gene with or without ESBL, OXA-48, and/or AmpC genes.