TABLE 1

Comparative analysis of diagnostic performance characteristics of urinary biomarkers with different severity grades of histopathology using area under the receiver operating characteristic curvesa

SubgroupBiomarker (ng/ml)Day 1 biomarkers predicting 24 h histopath (AUC [95% CI])Day 3 biomarkers predicting 72 h histopath (AUC [95% CI])Day 2 biomarkers predicting 144 h histopath (AUC [95% CI])Day 6 biomarkers predicting 144 h histopath (AUC [95% CI])
Histopath of ≥1NGAL0.320 (0.14–0.50)0.758 (0.61–0.91)0.649 (0.39–0.91)0.760 (0.56–0.96)
KIM-10.661 (0.50–0.82)0.923 (0.85–1.00)0.752 (0.59–0.91)0.918 (0.82–1.00)
Clusterin0.706 (0.55–0.86)0.892 (0.80–0.99)0.754 (0.59–0.92)0.889 (0.78–1.00)
OPN0.590 (0.41–0.77)0.952 (0.90–1.00)0.615 (0.41–0.82)0.757 (0.58–0.94)
Cystatin C0.483 (0.29–0.68)0.688 (0.49–0.89)0.692 (0.47–0.91)0.538 (0.29–0.78)
Histopath of ≥2NGAL0.381 (0.16–0.60)0.555 (0.36–0.75)0.668 (0.44–0.90)0.71 (0.53–0.89)
KIM-10.762 (0.46–1.00)0.822 (0.70–0.95)0.913 (0.79–1.00)0.90 (0.80–1.00)
Clusterin0.762 (0.52–1.00)0.801 (0.67–0.93)0.861 (0.74–1.00)0.82 (0.68–0.96)
OPN0.714 (0.46–0.97)0.695 (0.53–0.86)0.828 (0.68–0.98)0.85 (0.72–0.99)
Cystatin C0.394 (0.14–0.65)0.549 (0.37–0.72)0.695 (0.49–0.90)0.55 (0.34–0.76)
Histopath of ≥3NGALOutcome does not vary0.571 (0.37–0.77)0.931 (0.84–1.00)0.58 (0.40–0.76)
KIM-1Outcome does not vary0.476 (0.21–0.74)0.986 (0.95–1.00)0.83 (0.68–0.99)
ClusterinOutcome does not vary0.381 (0.23–0.53)0.793 (0.63–0.96)0.72 (0.53–0.92)
OPNOutcome does not vary0.511 (0.18–0.84)0.755 (0.60–0.91)0.69 (0.52–0.86)
Cystatin COutcome does not vary0.488 (0.00–1.00)0.813 (0.48–1.00)0.37 (0.16–0.57)
  • a AUC, area under the receiver operating characteristic curve; CI, confidence interval; NGAL, neutrophil gelatinase-associated lipocalin; KIM-1, kidney injury molecule-1; OPN, osteopontin.