TABLE 4

MICs for the synergistically interacting antifungal and nonantifungal ophthalmic agents natamycin and 5-fluorouracil

StrainMIC (μg/ml) of each agent aloneMIC (μg/ml) of each agent in the combinationFICIAvg FICI
Natamycin5-FluorouracilNatamycin5-Fluorouracil
F. solani
    132.02161,2508780.560.59
    26250.63
    06-0487162,50081560.560.56
    46250.50
    21,2500.63
    06-0330322,50016100.500.40
    81560.31
    46250.38
    06-0133322,50016100.500.34
    8780.28
    43130.25
    26250.31
    06-0111322,50016100.500.44
    81560.31
    46250.38
    21,2500.56
    06-0110322,50016100.500.40
    81560.31
    46250.38
F. oxysporum
    06-0342325,00016780.520.40
    83130.31
    41,2500.38
    06-0197165,00081560.530.55
41,2500.50
22,5000.63