TABLE 2

Population pharmacokinetic parameter estimates for the final arbekacin population pharmacokinetic modele

Exposure matrix and parameterPopulation meanInterindividual variability (%CV)
Final estimate%SEMFinal estimate%SEM
Plasma
    CLa (liters/h)32.118.6
        CL-weight power0.85515.2
        CL-CLcrn slope0.02897.37
        CL coefficient2.325.30
    Vc (liters)13.84.4319.341.9
    CLd1 (liters/h)0.90126.3
    Vp1 (liters)17.530.511350.7
    Additive errorb0.000669 (0.026)290
    Proportional errorb0.0603 (0.246)5.17
ELF
    Logit_bioavailability−1.42c8.380.460d24.2
    V1_ELF0.025522.6
    K310.89314.675.628.3
    K130.18623.2
    K340.10268.522353.1
    K430.22628.5
    Additive errorb2,050 (45.3)1,702
    Proportional errorb0.695 (0.834)71.2
  • a CL = (weight in kg/52.2)0.855·([CLcrn – 77]·0.0289 + 2.32).

  • b Population mean residual variability terms reported as variance (standard deviation).

  • c Translates to 19.5%.

  • d Interindividual variability is additive rather than proportional. Listed value is a standard deviation rather than a %CV.

  • e Minimum value of the objective function, n = 1,302.8.